7,7-Dimethylaporphine and Other Alkaloids from the Bark of Guatteria friesiana

J Nat Prod. 2016 Jun 24;79(6):1524-31. doi: 10.1021/acs.jnatprod.5b01037.

Emmanoel V Costa ¹, Maria Lúcia B Pinheiro ¹, Beatriz Helena L N S Maia ², Francisco A Marques ², Ana Lúcia T G Ruiz ³, Gabriela M Marchetti ³, João Ernesto de Carvalho ³, Milena B P Soares ⁴ ⁵, Cinara O S Costa ⁴, Alexandre F C Galvão ⁴, Norberto P Lopes ⁶, Hector H F Koolen ⁷, Daniel P Bezerra ⁴, Andersson Barison ²

Affiliations

1 Department of Chemistry, Federal University of Amazonas , Manaus 69077-000, Brazil.
2 Department of Chemistry, Federal University of Paraná , Curitiba 81531-990, Brazil.
3 Chemical, Biological and Agricultural Pluridisciplinary Research Center/CPQBA, University of Campinas , Paulínia 13083-970, Brazil.
4 Gonçalo Moniz Research Center, Oswaldo Cruz Foundation/CPqGM-FIOCRUZ , Salvador 40296-710, Brazil.
5 Biotechnology and Cell Therapy Center, São Rafael Hospital , Salvador 41253-190, Brazil.
6 Department of Chemistry and Physics, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo , Ribeirão Preto 14040-903, Brazil.
7 DeMpSter Mass Spectrometry Group, Amazonas State University , Manaus 69050-010, Brazil.

PMID: 27300257 DOI: 10.1021/acs.jnatprod.5b01037

Abstract

Phytochemical investigation of the bark of Guatteria friesiana afforded 12 new aporphines (1-12), along with nine known Alkaloids (13-21). The structures of the new Alkaloids were determined on the basis of spectroscopic data interpretation. The cytotoxic activity of the isolated compounds against a small panel of tumor cell lines was assessed using the Alamar blue assay.

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