2. Academic Validation
  3. Protective effects of phillyrin against influenza A virus in vivo

Protective effects of phillyrin against influenza A virus in vivo

  • Arch Pharm Res. 2016 Jul;39(7):998-1005. doi: 10.1007/s12272-016-0775-z.
Xin-Yan Qu 1,  Qing-Jun Li 1,  Hui-Min Zhang 2,  Xiao-Juan Zhang 1,  Peng-Hui Shi 1,  Xiu-Juan Zhang 1,  Jing Yang 3,  Zhe Zhou 4,  Sheng-Qi Wang 5
Affiliations

Affiliations

  • 1 Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, 100850, Beijing, People's Republic of China.
  • 2 Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250355, China.
  • 3 Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, 100850, Beijing, People's Republic of China. jingyang0511@sina.com.
  • 4 Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, 100850, Beijing, People's Republic of China. zhouzhe@bmi.ac.cn.
  • 5 Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, 100850, Beijing, People's Republic of China. sqwang@nic.bmi.ac.cn.
PMID: 27323762 DOI: 10.1007/s12272-016-0775-z
Abstract

Influenza A virus Infection represents a great threat to public health. However, owing to side effects and the emergence of resistant virus strains, the use of currently available anti-influenza drugs may be limited. In order to identify novel anti-influenza drugs, we investigated the Antiviral effects of phillyrin against influenza A virus Infection in vivo. The mean survival time, lung index, viral titers, Influenza Hemagglutinin (HA) protein and serum cytokines levels, and histopathological changes in lung tissue were examined. Administration of phillyrin at a dose of 20 mg/kg/day for 3 days significantly prolonged the mean survival time, reduced the lung index, decreased the virus titers and interleukin-6 levels, reduced the expression of HA, and attenuated lung tissue damage in mice infected with influenza A virus. Taken together, these data showed that phillyrin had potential protective effects against Infection caused by influenza A virus.

Keywords

Influenza A virus; Mouse; Phillyrin.

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