2. Academic Validation
  3. The anti-diabetic activity of oat β-d-glucan in streptozotocin-nicotinamide induced diabetic mice

The anti-diabetic activity of oat β-d-glucan in streptozotocin-nicotinamide induced diabetic mice

  • Int J Biol Macromol. 2016 Oct:91:1170-6. doi: 10.1016/j.ijbiomac.2016.06.083.
Mei Liu 1,  Yu Zhang 2,  Hui Zhang 3,  Bo Hu 4,  Li Wang 5,  Haifeng Qian 6,  Xiguang Qi 7
Affiliations

Affiliations

  • 1 State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: waitliumei@foxmail.com.
  • 2 State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: chumenghen123@gmail.com.
  • 3 State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: zhanghui@jiangnan.edu.cn.
  • 4 State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: 615159020@qq.com.
  • 5 State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: nmrwl@yahoo.com.cn.
  • 6 State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: 576589831@qq.com.
  • 7 State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: 307957312@qq.com.
PMID: 27365119 DOI: 10.1016/j.ijbiomac.2016.06.083
Abstract

This study was initiated to investigate the mechanism by which OAT β-d-glucan (OBG) can control blood sugar levels and improve hepatogenic glycometabolism in streptozotocin-nicotinamide induced mice. After administration of different concentrations and molecular weights of β-d-glucan by oral gavage for 28 days, the body weight, fasting blood glucose, serum Insulin, hepatic glycogen, glucose kinase and glucose-6-phosphatase activity of the diabetic mice were measured. In comparison with a negative control group (saline), β-d-glucan, especially medium or high doses of high-molecular-weight β-d-glucan, had a strong hypoglycaemic effect in streptozotocin-nicotinamide-induced mice. The mechanism of this effect may be associated with the high viscosity of the solution, an increase in Insulin secretion, a decline in Insulin resistance, and especially an improvement in hepatogenic glycometabolism. Moreover, β-d-glucan also markedly repaired and improved the integrity of pancreatic islet β-cell and tissue structures.

Keywords

Diabetes; Hepatogenic glycometabolism; β-d-glucan.

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