Chemical Constituents Isolated from the Root Bark of Cudrania tricuspidata and Their Potential Neuroprotective Effects

J Nat Prod. 2016 Aug 26;79(8):1938-51. doi: 10.1021/acs.jnatprod.6b00204.

Jaeyoung Kwon, Nguyen Tuan Hiep, Dong-Woo Kim ¹, Sungeun Hong ¹, Yuanqiang Guo ², Bang Yeon Hwang ³, Hak Ju Lee ⁴, Woongchon Mar ¹, Dongho Lee

Affiliations

1 Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 08826, Republic of Korea.
2 State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.
3 College of Pharmacy, Chungbuk National University , Cheongju 28644, Republic of Korea.
4 Korea Forest Research Institute , Seoul 02455, Republic of Korea.

PMID: 27420919 DOI: 10.1021/acs.jnatprod.6b00204

Abstract

Seventy-five compounds, including 21 new compounds (1-21), were isolated from the root bark of Cudrania tricuspidata. The structures of the isolated compounds were elucidated by interpretation of their spectroscopic data. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death, and nine compounds had activities with EC50 values of 1.9-30.2 μM. The 75 isolated compounds along with 34 previously reported Xanthones were tested also for neuroprotective effects against the 1-methyl-4-phenylpyridinium ion (MPP(+)) and oxygen glucose deprivation (OGD)-induced cell death. Three compounds were active against MPP(+)-induced cell death with EC50 values of 0.2-10.3 μM, and 23 compounds were active in the OGD model with EC50 values of 2.9-35.5 μM.

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