2. Academic Validation
  3. Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines

Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines

  • Bioorg Med Chem Lett. 2016 Aug 15;26(16):3955-7. doi: 10.1016/j.bmcl.2016.07.007.
Germán F Giri 1,  Mauro Danielli 2,  Raúl A Marinelli 2,  Rolando A Spanevello 1
Affiliations

Affiliations

  • 1 Instituto de Química de Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario-CONICET, Suipacha 531, S2002LRK Rosario, Argentina.
  • 2 Instituto de Fisiología Experimental, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario-CONICET, Suipacha 531, S2002LRK Rosario, Argentina.
PMID: 27422336 DOI: 10.1016/j.bmcl.2016.07.007
Abstract

Levoglucosenone has been used as template for the synthesis of a wide variety of compounds with an impressive structural variability. However, scarce work has been done regarding the generation of new bioactive entities. Here we report the cytotoxic effect of levoglucosenone and some related derivatives against hepatocarcinoma cell lines. Compounds were obtained in only one synthetic step and one of them showed an activity within the range of IC50 values of cisplatin, a frequently administered chemotherapy drug.

Keywords

Cancer cell lines; Cytotoxic activity; Hepatocarcinoma; Levoglucosenone; Michael addition.

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