2. Academic Validation
  3. Cantharimide and Its Derivatives from the Blister Beetle Mylabris phalerata Palla

Cantharimide and Its Derivatives from the Blister Beetle Mylabris phalerata Palla

  • J Nat Prod. 2016 Aug 26;79(8):2032-8. doi: 10.1021/acs.jnatprod.6b00332.
Yao-Bo Zeng 1,  Xiao-Ling Liu 1,  Yi Zhang 1,  Chuang-Jun Li 2,  Dong-Ming Zhang 2,  Yao-Zong Peng 3,  Xing Zhou 1,  Hong-Fei Du 1,  Chun-Bing Tan 1,  Yu-Yu Zhang 1,  Da-Jian Yang 1
Affiliations

Affiliations

  • 1 Chongqing Academy of Chinese Material Medical , Chongqing, 400065, People's Republic of China.
  • 2 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (State Key Laboratory of Bioactive Substance and Function of Natural Medicines) , Beijing, 100050, People's Republic of China.
  • 3 School of Pharmaceutical Sciences, Southwest University , Chongqing, 400715, People's Republic of China.
PMID: 27458783 DOI: 10.1021/acs.jnatprod.6b00332
Abstract

Eleven new monoterpenoids including three 1-methyl cantharimide-type derivatives (1-3), five 1,2-dimethyl cantharimide-type derivatives (4, 5, 7-9), and three 1-hydroxymethyl-2-methyl cantharimide-type derivatives (10-12), together with seven known cantharimides (6, 13-18), were isolated from Mylabis phalerata Palla. The planar structures and absolute configurations of compounds 1-14 were fully elucidated on the basis of spectroscopic analysis, ECD spectra, single-crystal X-ray diffraction analysis, and chemical methods. Compounds 6, 15, 16, and 18 were found to be potent inhibitors of HBV virus, with IC50 values of 62, 42, 58, and 19 μM.

Figures