2. Academic Validation
  3. Polyphenols from wolfberry and their bioactivities

Polyphenols from wolfberry and their bioactivities

  • Food Chem. 2017 Jan 1:214:644-654. doi: 10.1016/j.foodchem.2016.07.105.
Zheng-Qun Zhou 1,  Jia Xiao 2,  Hong-Xia Fan 1,  Yang Yu 1,  Rong-Rong He 1,  Xiao-Lin Feng 1,  Hiroshi Kurihara 1,  Kwok-Fai So 3,  Xin-Sheng Yao 4,  Hao Gao 5
Affiliations

Affiliations

  • 1 Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
  • 2 Department of Immunobiology, Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou 510632, People's Republic of China.
  • 3 Guangdong Medical Key Laboratory of Brain Function and Diseases, GMH Institute of Central Nervous System Regeneration, Jinan University, Guangzhou 510632, People's Republic of China.
  • 4 Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address: tyaoxs@jnu.edu.cn.
  • 5 Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address: tghao@jnu.edu.cn.
PMID: 27507521 DOI: 10.1016/j.foodchem.2016.07.105
Abstract

Nine new Phenylpropanoids, one new coumarin, and 43 known Polyphenols were isolated from wolfberry. Their structures were determined by spectroscopic analyses, chemical methods, and comparison of NMR data. Polyphenols, an important type of Natural Products, are notable constituents in wolfberry. 53 Polyphenols, including 28 Phenylpropanoids, four Coumarins, eight Lignans, five Flavonoids, three isoflavonoids, two chlorogenic acid derivatives, and three other constituents, were identified from wolfberry. Lignans and isoflavonoids were firstly reported from wolfberry. 22 known Polyphenols were the first isolates from the genus Lycium. This research presents a systematic study on wolfberry Polyphenols, including their bioactivities. All these compounds exhibited oxygen radical absorbance capacity (ORAC), and some compounds displayed DPPH radical scavenging activity. One compound had acetylcholinesterase inhibitory activity. The discovery of new Polyphenols and their bioactivities is beneficial for understanding the scientific basis of the effects of wolfberry.

Keywords

DPPH radical scavenging assay; Ellman method; Lycium barbarum; ORAC assay; Polyphenols; Structural identification; ThT assay; Wolfberry.

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