2. Academic Validation
  3. Synthesis of novel hydrazone and azole functionalized pyrazolo[3,4-b]pyridine derivatives as promising anticancer agents

Synthesis of novel hydrazone and azole functionalized pyrazolo[3,4-b]pyridine derivatives as promising anticancer agents

  • Bioorg Med Chem Lett. 2016 Sep 15;26(18):4427-4432. doi: 10.1016/j.bmcl.2016.08.006.
P Nagender 1,  R Naresh Kumar 1,  G Malla Reddy 1,  D Krishna Swaroop 1,  Y Poornachandra 2,  C Ganesh Kumar 2,  B Narsaiah 3
Affiliations

Affiliations

  • 1 Fluoroorganic Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
  • 2 Chemical Biology Laboratory, Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
  • 3 Fluoroorganic Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India. Electronic address: narsaiah@iict.res.in.
PMID: 27528432 DOI: 10.1016/j.bmcl.2016.08.006
Abstract

A series of novel pyrazolo[3,4-b]pyridine based target compounds were synthesized starting from the key intermediate ethyl 2-(3-amino-6-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate 5 on reaction with hydrazine hydrate followed by reaction with different aldehydes, acid chlorides and isothiocyanates to form hydrazones 7, oxadiazoles 8, 1,2,4 triazoles 10 and thiadiazoles 11 respectively in high yield. All the final compounds were screened for Anticancer activity against four human Cancer cell lines. Among them, 1,2,4 triazole derivatives showed promising activity and compound 10d is identified as a lead molecule.

Keywords

1,2,4-Triazole; Anticancer activity; Oxadiazole; Pyrazolo[3,4-b]pyridine.

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