2. Academic Validation
  3. Halogenated Sesquiterpenoids from the Red Alga Laurencia tristicha Collected in Taiwan

Halogenated Sesquiterpenoids from the Red Alga Laurencia tristicha Collected in Taiwan

  • J Nat Prod. 2016 Sep 23;79(9):2315-23. doi: 10.1021/acs.jnatprod.6b00452.
Jia-Yu Chen,  Chiung-Yao Huang,  Yun-Sheng Lin 1,  Tsong-Long Hwang 2,  Wei-Lung Wang 3,  Shu-Fen Chiou,  Jyh-Horng Sheu 4 5
Affiliations

Affiliations

  • 1 Department of Biological Science & Technology, Mei Ho University , Pingtung 912, Taiwan.
  • 2 Graduate Institute of Natural Products, College of Medicine, Chang Gung University ; Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology; and Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
  • 3 Department of Biology, National Changhua University of Education , Changhua 500, Taiwan.
  • 4 Institute of Natural Products, Kaohsiung Medical University , Kaohsiung 807, Taiwan.
  • 5 Department of Medical Research, China Medical University Hospital, China Medical University , Taichung 404, Taiwan.
PMID: 27536968 DOI: 10.1021/acs.jnatprod.6b00452
Abstract

Chemical investigation of the red alga Laurencia tristicha led to the discovery of eight new halogenated chamigrane-type sesquiterpenoids (1-8) and one new bromocuparane-type sesquiterpene (9), along with nine known related metabolites (10-18). Their structures were elucidated on the basis of extensive spectroscopic analyses, and the absolute configurations of 1-8 were proposed by comparison to the biosynthetically related known compound 12. Cytotoxicity, Antibacterial, and anti-inflammatory activities of these isolates were also investigated. The results showed that compound 11 exhibited good Antibacterial activity against Serratia marcescens compared to the positive control ampicillin at a dosage of 100 μg/disk. Compound 17 showed strong inhibition toward Elastase release generation at 10 μM.

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