2. Academic Validation
  3. Three New Isoprenylated Flavonoids from the Root Bark of Morus alba

Three New Isoprenylated Flavonoids from the Root Bark of Morus alba

  • Molecules. 2016 Aug 24;21(9):1112. doi: 10.3390/molecules21091112.
Jae-Woo Jung 1,  Ji-Hae Park 2,  Yeong-Geun Lee 3,  Kyeong-Hwa Seo 4,  Eun-Ji Oh 5,  Dae-Young Lee 6,  Dong-Wook Lim 7,  Daeseok Han 8,  Nam-In Baek 9
Affiliations

Affiliations

  • 1 Graduate School of Biotechnology and Oriental Medicine Biotechnology, Kyung Hee University, Yongin 17104, Korea. jaewoo4848@naver.com.
  • 2 Graduate School of Biotechnology and Oriental Medicine Biotechnology, Kyung Hee University, Yongin 17104, Korea. pjh3411@kbsi.re.kr.
  • 3 Graduate School of Biotechnology and Oriental Medicine Biotechnology, Kyung Hee University, Yongin 17104, Korea. lyg629@nate.com.
  • 4 Natural Medicine Research Center, KRIBB, Chengju 28116, Korea. khseo@kribb.re.kr.
  • 5 Graduate School of Biotechnology and Oriental Medicine Biotechnology, Kyung Hee University, Yongin 17104, Korea. JK3172@nate.com.
  • 6 Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 27709, Korea. dylee0809@korea.kr.
  • 7 Division of Metabolism and Functionality Research, Korea Food Research Institute, Sungnam 463-746, Korea. neodw4015@kfri.re.kr.
  • 8 Division of Metabolism and Functionality Research, Korea Food Research Institute, Sungnam 463-746, Korea. imissu@kfri.re.kr.
  • 9 Graduate School of Biotechnology and Oriental Medicine Biotechnology, Kyung Hee University, Yongin 17104, Korea. nibaek@khu.ac.kr.
PMID: 27563860 DOI: 10.3390/molecules21091112
Abstract

Phytochemical investigation of the root bark of Morus alba has led to the isolation and identification of three new isoprenylated Flavonoids, namely sanggenon U (1), sanggenon V (2), and sanggenon W (3), along with four known isoprenylated flavonoids: euchrenone a₇ (4), sanggenon J (5), kuwanon E (6), and kuwanon S (7). All compounds were isolated by repeated silica gel (SiO₂), octadecyl SiO₂ (ODS), and Sephadex LH-20 open column chromatography. The structure of the compounds were determined based on spectroscopic analyses, including nuclear magnetic resonance (NMR), mass spectrometry (MS), circular dichroism (CD), and infrared (IR). In addition, compounds 1-4 were isolated for the first time from the root bark of M. alba in this study.

Keywords

Morus alba; isoprenylated flavonoids; root bark; sanggenon U; sanggenon V; sanggenon W.

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