New labdane diterpenoids from Croton laui and their anti-inflammatory activities

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4687-4691. doi: 10.1016/j.bmcl.2016.08.052.

Li Yang ¹, Yu-Bo Zhang ¹, Li-Feng Chen ¹, Neng-Hua Chen ¹, Zhong-Nan Wu ¹, Si-Qi Jiang ¹, Lin Jiang ¹, Guo-Qiang Li ¹, Yao-Lan Li ², Guo-Cai Wang ³

Affiliations

1 Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
2 Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: tliyl@jnu.edu.cn.
3 Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: twangguocai@jnu.edu.cn.

PMID: 27575472 DOI: 10.1016/j.bmcl.2016.08.052

Abstract

Nine new labdane Diterpenoids (1-9) were isolated from the aerial parts of Croton laui, along with eight known analogues (10-17). Their structures were identified on the basis of the spectral data (IR, UV, HRESIMS, 1D and 2D NMR), and the structure of 8 was confirmed by single crystal X-ray diffraction analyses. In addition, compounds 1, 4, 7, 8, and 14 showed weak anti-inflammatory activities in LPS-stimulated RAW 264.7 cells.

Keywords

Anti-inflammatory activity; Croton laui; Labdane diterpenoid.

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