2. Academic Validation
  3. FAM122A, a new endogenous inhibitor of protein phosphatase 2A

FAM122A, a new endogenous inhibitor of protein phosphatase 2A

  • Oncotarget. 2016 Sep 27;7(39):63887-63900. doi: 10.18632/oncotarget.11698.
Li Fan 1,  Man-Hua Liu 1,  Meng Guo 2,  Chuan-Xi Hu 2,  Zhao-Wen Yan 2,  Jing Chen 1,  Guo-Qiang Chen 1 2,  Ying Huang 2
Affiliations

Affiliations

  • 1 Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • 2 Institute of Health Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
PMID: 27588481 DOI: 10.18632/oncotarget.11698
Abstract

The regulation of the ubiquitously expressed protein Phosphatase 2A (PP2A) is essential for various cellular functions such as cell proliferation, transformation, and fate determination. In this study, we demonstrate that the highly conserved protein in mammals, designated FAM122A, directly interacts with PP2A-Aα and B55α rather than B56α subunits, and inhibits the Phosphatase activity of PP2A-Aα/B55α/Cα complex. Further, FAM122A potentiates the degradation of catalytic subunit PP2A-Cα with the increased poly-ubiquitination. In agreement, FAM122A silencing inhibits while its overexpression enhances cell growth and colony-forming ability. Collectively, we identify FAM122A as a new endogenous PP2A inhibitor and its physiological and pathophysiological significances warrant to be further investigated.

Keywords

FAM122A; PP2A; cell growth; phosphatase activity; ubiquitination.

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