2. Academic Validation
  3. Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

  • Molecules. 2016 Aug 29;21(9):1146. doi: 10.3390/molecules21091146.
Dongsheng Fan 1,  Guo-Yuan Zhu 2,  Ting Li 3,  Zhi-Hong Jiang 4,  Li-Ping Bai 5
Affiliations

Affiliations

  • 1 State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. fandongsheng1985@sina.com.
  • 2 State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. gyzhu@must.edu.mo.
  • 3 State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. tli@must.edu.mo.
  • 4 State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. zhjiang@must.edu.mo.
  • 5 State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. lpbai@must.edu.mo.
PMID: 27589701 DOI: 10.3390/molecules21091146
Abstract

Two new dimacrolide sesquiterpene Pyridine Alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3'-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second macrocyclic ring system. Compound 2 showed inhibitory effects on the proliferation of human rheumatoid arthritis synovial fibroblast cell (MH7A) at a concentration of 20 μM.

Keywords

Tripterygium regelii; anti-inflammation; dimacrolide sesquiterpene pyridine alkaloids.

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