2. Academic Validation
  3. Vetiverianines A, B, and C: Sesquiterpenoids from Vetiveria zizanioides Roots

Vetiverianines A, B, and C: Sesquiterpenoids from Vetiveria zizanioides Roots

  • J Nat Prod. 2016 Sep 23;79(9):2175-80. doi: 10.1021/acs.jnatprod.6b00140.
Yukiko Matsuo 1,  Saori Maeda 1,  Chika Ohba 1,  Haruhiko Fukaya 1,  Yoshihiro Mimaki 1
Affiliations

Affiliation

  • 1 School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
PMID: 27598828 DOI: 10.1021/acs.jnatprod.6b00140
Abstract

Three new sesquiterpenoids-vetiverianines A (1), B (2), and C (3)-and a known eudesmane sesquiterpenoid (4) were isolated from the roots of Vetiveria zizanioides. Vetiverianine A (1) has a unique carbon framework comprising a rigid tricyclic ring system. Vetiverianines B (2) and C (3) are new eremophilane sesquiterpenoids. The structures of sesquiterpenoids 1-3, including the absolute configurations, were determined by NMR spectroscopic, X-ray crystallography, and vibrational circular dichroism data analysis. Vetiverianine C (3) exhibited weak cytotoxic activity against HL-60 cells.

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