1. Academic Validation
  2. Columnaristerol A, a novel 19-norsterol from the Formosan octocoral Nephthea columnaris

Columnaristerol A, a novel 19-norsterol from the Formosan octocoral Nephthea columnaris

  • Bioorg Med Chem Lett. 2016 Oct 15;26(20):4966-4969. doi: 10.1016/j.bmcl.2016.09.007.
Ta-Yuan Whuang 1 Wen-Cheng Tsai 2 Nan-Fu Chen 3 Zhi-Cheng Chen 4 Kuan-Hao Tsui 5 Zhi-Hong Wen 6 Yin-Di Su 7 Yu-Chia Chang 8 Yu-Hsin Chen 9 Mei-Chin Lu 1 Lee-Shing Fang 10 Jih-Jung Chen 11 Tung-Ying Wu 12 Yang-Chang Wu 13 Ping-Jyun Sung 14
Affiliations

Affiliations

  • 1 Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
  • 2 Medicine Department, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 833, Taiwan.
  • 3 Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan; Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
  • 4 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
  • 5 Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan; Department of Obstetrics and Gynecology and Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan; Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan.
  • 6 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan.
  • 7 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
  • 8 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan.
  • 9 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.
  • 10 Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan.
  • 11 Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan.
  • 12 Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan.
  • 13 Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan; School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: yachwu@mail.cmu.edu.tw.
  • 14 Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: pjsung@nmmba.gov.tw.
Abstract

Columnaristerol A (1), a rare natural 19-norsterol possessing a 10β-hydroxy group was isolated from the Formosan octocoral Nephthea columnaris, and its structure was elucidated by spectroscopic methods. Sterol 1 was found to be a cytotoxic agent that exhibited in vitro moderate cytotoxic activity against MOLT-4 and SUP-T1 human leukemia-lymphoma cell lines.

Keywords

19-Norsterol; Columnaristerol; Cytotoxicity; Nephthea columnaris.

Figures