2. Academic Validation
  3. Plasminogen deficiency

Plasminogen deficiency

  • J Thromb Thrombolysis. 2017 Jan;43(1):132-138. doi: 10.1007/s11239-016-1416-6.
Tiraje Celkan 1
Affiliations

Affiliation

  • 1 Departments of Pediatric Hematology-Oncology, Cerrahpasa Faculty of Medicine, İstanbul University, Armakent B2/8 Konaklar Mah. Şebboy Sok. 4.Levent-İstanbul, 80620, Istanbul, Turkey. tirajecelkan@yahoo.com.
PMID: 27629020 DOI: 10.1007/s11239-016-1416-6
Abstract

Plasminogen plays an important role in fibrinolysis as well as wound healing, cell migration, tissue modeling and angiogenesis. Congenital plasminogen deficiency is a rare autosomal recessive disorder that leads to the development of thick, wood-like pseudomembranes on mucosal surfaces, mostly seen in conjunctivas named as ''ligneous conjunctivitis''. Local conjunctival use of fresh frozen plazma (FFP) in combination with Other eye medications such as cyclosporin and artificial tear drops may relieve the symptoms. Topical treatment with plasminogen eye drops is the most promising treatment that is not yet available in Turkey.

Keywords

Hydrocephalus; Ligneous conjunctivitis; Ligneous gingivitis; Plasminogen deficiency.

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