2. Academic Validation
  3. Sesquiterpenes from the roots of Lindera strychnifolia with inhibitory effects on nitric oxide production in RAW 264.7 cells

Sesquiterpenes from the roots of Lindera strychnifolia with inhibitory effects on nitric oxide production in RAW 264.7 cells

  • Bioorg Med Chem Lett. 2016 Oct 15;26(20):4950-4954. doi: 10.1016/j.bmcl.2016.09.012.
Qing Liu 1,  Yang Hee Jo 1,  Seon Beom Kim 1,  Qinghao Jin 1,  Bang Yeon Hwang 1,  Mi Kyeong Lee 2
Affiliations

Affiliations

  • 1 College of Pharmacy, Chungbuk National University, Chungdae-ro, Seowon-gu, Cheongju 28644, Republic of Korea.
  • 2 College of Pharmacy, Chungbuk National University, Chungdae-ro, Seowon-gu, Cheongju 28644, Republic of Korea. Electronic address: mklee@chungbuk.ac.kr.
PMID: 27634197 DOI: 10.1016/j.bmcl.2016.09.012
Abstract

Seven new Sesquiterpenes, linderolides N-T (1-7), along with nine known compounds, were isolated from roots of Lindera strychnifolia (Lauraceae). Their structures were established by extensive spectroscopic analysis. The relative and absolute configurations were determined by NOESY and CD analysis, respectively. Among the isolated compounds, two new compounds, linderolide O (2) and linderolide P (3) inhibited lipopolysaccharide-stimulated nitric oxide production in murine RAW 264.7 macrophage cells, with IC50 values of 6.3 and 9.6μM, respectively.

Keywords

Anti-inflammation; Lauraceae; Lindera strychnifolia; Linderolides N–T; Sesquiterpene.

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