2. Academic Validation
  3. Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn

Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn

  • Bioorg Med Chem Lett. 2016 Nov 15;26(22):5501-5506. doi: 10.1016/j.bmcl.2016.10.012.
Ying Peng 1,  Li-Li Lou 2,  Si-Fan Liu 2,  Le Zhou 2,  Xiao-Xiao Huang 3,  Shao-Jiang Song 4
Affiliations

Affiliations

  • 1 School of Pharmacy, Shenyang Pharmaceutical University, PR China.
  • 2 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, PR China.
  • 3 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, PR China. Electronic address: xiaoxiao270@163.com.
  • 4 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, PR China. Electronic address: songsj99@163.com.
PMID: 27765508 DOI: 10.1016/j.bmcl.2016.10.012
Abstract

Seven new neolignans (1-2, 7-11) and five known compounds (3-6, 12) were isolated from the 70% EtOH extract of hawthorn seeds. Their structures were determined by spectroscopic analyses. The antioxidant and anti-inflammatory activities of all the isolates were investigated. Most of the isolates showed moderate radical scavenging activity in the DPPH assay and significant activities in the ABTS and FRAP assays. Furthermore, compounds 7-12 exhibited marked nitric oxide (NO) inhibition and compounds 1-4 had a potent necrosis factor-α (TNF-α) inhibitory effect. The results we obtained showed that hawthorn seeds can be regarded as a potential new and cheap source of Antioxidants and inflammation inhibitors.

Keywords

Anti-inflammatory; Antioxidant; Crataegus pinnatifida; Hawthorn; Neolignan; Seeds.

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