1. Academic Validation
  2. The complement and contact activation systems: partnership in pathogenesis beyond angioedema

The complement and contact activation systems: partnership in pathogenesis beyond angioedema

  • Immunol Rev. 2016 Nov;274(1):281-289. doi: 10.1111/imr.12469.
Berhane Ghebrehiwet 1 Allen P Kaplan 2 Kusumam Joseph 2 Ellinor I B Peerschke 3 4
Affiliations

Affiliations

  • 1 The Departments of Medicine and Pathology, Stony Brook University, Stony Brook, NY, USA. berhane.ghebrehiwet@stonybrookmedicine.edu.
  • 2 Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • 3 The Department of Laboratory Medicine, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY, USA.
  • 4 The Department of Pathology, Weill-Cornell Medical College, New York, NY, USA.
Abstract

The blood plasma contains four biologically important proteolytic cascades, which probably evolved from the same ancestral gene. This in part may explain why each cascade has very similar "initiating trigger" followed by sequential and cascade-like downstream enzymatic activation pattern. The four cascades are: the Complement System, the blood clotting cascade, the fibrinolytic system, and the kallikrein-kinin system. Although much has been written about the interplay between all these enzymatic cascades, the cross-talk between the complement and the kinin generating systems has become particularly relevant as this interaction results in the generation of nascent molecules that have significant impact in various inflammatory diseases including angioedema and Cancer. In this review, we will focus on the consequences of the interplay between the two systems by highlighting the role of a novel molecular link called gC1qR. Although this protein was first identified as a receptor for C1q, it is now recognized as a multiligand binding cellular protein, which serves not only as C1q receptor, but also as high affinity (KD ≤ 0.8 nM) binding site for both high molecular weight kininogen (HK) and factor XII (FXII). At inflammatory sites, where atherogenic factors such as immune complexes and/or pathogens can activate the endothelial cell into a procoagulant and proinflammatory surface, the two pathways are activated to generate vasoactive Peptides that contribute in various ways to the inflammatory processes associated with numerous diseases. More importantly, since recent observations strongly suggest an important role for both pathways in Cancer, we will focus on how a growing tumor cluster can employ the byproducts derived from the two activation systems to ensure not only its survival and growth, but also its escape into distal sites of colonization.

Keywords

bradykinin; complement; contact activation; gC1qR; kinin-kallikrein system.

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