2. Academic Validation
  3. Tzumin A and B, two new lignan derivatives from the barks of Sassafras tzumu

Tzumin A and B, two new lignan derivatives from the barks of Sassafras tzumu

  • Nat Prod Res. 2017 Apr;31(7):829-834. doi: 10.1080/14786419.2016.1250085.
Haixiao Lu 1 2,  Feiyan Wu 1,  Meixiao Jiang 1,  Weijiang Liang 2
Affiliations

Affiliations

  • 1 a Department of Pharmaceutical Engineering , College of Biology & Pharmacy, Yulin Normal University , Yulin , P. R. China.
  • 2 b Guangxi Key Laboratory of Farm Products Processing (Cultivation Base) , Yulin Normal University , Yulin , P. R. China.
PMID: 27784172 DOI: 10.1080/14786419.2016.1250085
Abstract

Two new lignan compounds, 5'-allyl-2,2'-dihydroxy-[1,1'-biphenyl]-5-carboxylic acid (1) and 4,4'-diallyl-[1,1'-biphenyl]-2,2'-diol (2), together with four known compounds (3-6), were isolated from the barks of Sassafras tzumu. The new compounds were determined by NMR (1H and 13C NMR, HSQC, HMBC, 1H-1H COSY, NOESY/ROESY), and MS analysis. Compounds 1-3 showed potent AChE inhibitory activities, with IC50 values of 2.00, 1.81 and 1.91 μM, respectively.

Keywords

AChE inhibitory activities; Sassafras tzumu; lignan.

Figures
Products