Cytotoxic lanostanes from fruits of Garcinia wallichii Choisy (Guttiferae)

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5773-5779. doi: 10.1016/j.bmcl.2016.10.045.

Sakchai Hongthong ¹, Jatuporn Meesin ¹, Phanruethai Pailee ², Darunee Soorukram ¹, Palangpon Kongsaeree ¹, Samran Prabpai ¹, Pawinee Piyachaturawat ³, Surawat Jariyawat ³, Kanoknetr Suksen ³, Thaworn Jaipetch ⁴, Narong Nuntasaen ⁵, Vichai Reutrakul ¹, Chutima Kuhakarn ⁶

Affiliations

1 Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
2 Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand.
3 Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
4 Mahidol University, Kanchanaburi Campus, Saiyok, Kanchanaburi 71150, Thailand.
5 The Forest Herbarium National Park, Wildlife and Plant Conservation Department, Ministry of Natural Resources and Environment, Bangkok, Thailand.
6 Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand. Electronic address: chutima.kon@mahidol.ac.th.

PMID: 27793565 DOI: 10.1016/j.bmcl.2016.10.045

Abstract

Five new lanostanes, wallichinanes A-E (1-5) together with a known lanostane derivative 6 were isolated from the cytotoxic hexanes extract of fruits of Garcinia wallichii Choisy (Guttiferae). The structures of the isolated compounds were established by analysis of spectroscopic data, X-ray diffraction technique as well as comparison with the literature data. The cytotoxicity of all isolated compounds against a panel of cultured Cancer cell lines was evaluated. Compound 4 exhibited good cytotoxicity with ED₅₀ values ranging from 3.91 to 7.63μM.

Keywords

Cytotoxicity; Garcinia wallichii; Guttiferae; Lanostane; Triterpene.

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