2. Academic Validation
  3. Morphological Effect of the New Antifungal Agent ME1111 on Hyphal Growth of Trichophyton mentagrophytes, Determined by Scanning and Transmission Electron Microscopy

Morphological Effect of the New Antifungal Agent ME1111 on Hyphal Growth of Trichophyton mentagrophytes, Determined by Scanning and Transmission Electron Microscopy

  • Antimicrob Agents Chemother. 2016 Dec 27;61(1):e01195-16. doi: 10.1128/AAC.01195-16.
Yayoi Nishiyama 1,  Sho Takahata 2,  Shigeru Abe 3
Affiliations

Affiliations

  • 1 Teikyo University Institute of Medical Mycology, Tokyo, Japan ynishiya@main.teikyo-u.ac.jp.
  • 2 Meiji Seika Pharma Co., Ltd., Tokyo, Japan.
  • 3 Teikyo University Institute of Medical Mycology, Tokyo, Japan.
PMID: 27799213 DOI: 10.1128/AAC.01195-16
Abstract

The effects of ME1111, a novel Antifungal agent, on the hyphal morphology and ultrastructure of Trichophyton mentagrophytes were investigated by using scanning and transmission electron microscopy. Structural changes, such as pit formation and/or depression of the cell surface, and degeneration of intracellular organelles and plasmolysis were observed after treatment with ME1111. Our results suggest that the inhibition of energy production by ME1111 affects the integrity and function of cellular membranes, leading to Fungal cell death.

Keywords

antifungal agents; electron microscopy; mode of action; morphology.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-108012
    99.95%, Antifungal Agent