2. Academic Validation
  3. Bioactive chemical constituents from the root bark of Morus australis

Bioactive chemical constituents from the root bark of Morus australis

  • Bioorg Med Chem Lett. 2017 Jan 15;27(2):309-313. doi: 10.1016/j.bmcl.2016.11.046.
Yu-Ren Liao 1,  Ping-Chung Kuo 1,  Wei-Jern Tsai 2,  Guan-Jhong Huang 3,  Kuo-Hsiung Lee 4,  Tian-Shung Wu 5
Affiliations

Affiliations

  • 1 School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, ROC.
  • 2 Division of Chinese Medicine Literature and Informatics, National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC.
  • 3 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan, ROC.
  • 4 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States; Chinese Medicinal Research and Development Center, China Medical University Hospital, China Medical University, Taichung 404, Taiwan, ROC. Electronic address: khlee@unc.edu.
  • 5 School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, ROC; Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan, ROC.
PMID: 27908762 DOI: 10.1016/j.bmcl.2016.11.046
Abstract

Two new pyranoflavonoids, morustralins A (1) and B (2), a new natural benzene derivative, one benzenoid (Z)-1-hydroxy-4-(2-nitroethenyl)benzene (3), and thirty known compounds were isolated and characterized from the root bark of Morus australis. The structures of the new compounds were established from spectroscopic and spectrometric analyses. Ten isolates (1-10) were examined for inhibitory effects on adenosine diphosphate (ADP)-, arachidonic acid (AA)-, and platelet-aggregating factor (PAF)-induced platelet aggregation. Among the tested compounds, compound 3 displayed the most significant inhibition of ADP- and AA-induced platelet aggregation with IC50 values of 9.76±5.54 and 9.81±2.7μM, respectively. In addition, eight purified compounds (3-10) were examined for inhibition of nitric oxide (NO) production in RAW 264.7 cells and six compounds (3-8) displayed significant inhibitory effects with IC50 values ranging from 2.1±0.3 to 6.3±0.6μM.

Keywords

Anti-platelet aggregation; Morus australis; NO inhibitory activity; Pyranoflavonoid.

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