2. Academic Validation
  3. α-Glucosidase Inhibitors from the Marine-Derived Fungus Aspergillus flavipes HN4-13

α-Glucosidase Inhibitors from the Marine-Derived Fungus Aspergillus flavipes HN4-13

  • J Nat Prod. 2016 Nov 23;79(11):2977-2981. doi: 10.1021/acs.jnatprod.6b00766.
Cong Wang 1,  Lei Guo 1 2,  Jiejie Hao 1,  Liping Wang 3,  Weiming Zhu 1
Affiliations

Affiliations

  • 1 Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
  • 2 Jiangsu Marine Resources Development Research Institute, School of Marine Life and Fisheries, Huaihai Institute of Technology , Lianyungang 222004, People's Republic of China.
  • 3 Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002, People's Republic of China.
PMID: 27933892 DOI: 10.1021/acs.jnatprod.6b00766
Abstract

Three new butenolide derivatives, flavipesolides A-C (1-3), along with 13 known compounds (4-13, aspulvinone Q, monochlorosulochrin, and dihydrogeodin), were isolated from the marine-derived Aspergillus flavipes HN4-13 from a Lianyungang coastal sediment sample. The structures were elucidated by spectroscopic evidence. Compounds 4-6 and 9 were noncompetitive α-glucosidase inhibitors with Ki/IC50 values of 0.43/34, 2.1/37, 0.79/19, and 2.8/90 μM, respectively. Compounds 1-3, 8, 10, and 13 are mixed α-glucosidase inhibitors with Ki/IC50 values of (2.5, 19)/44, (3.4, 14)/57, (9.2, 4.7)/95, (6.3, 5.5)/55, (1.4, 0.60)/9.9, and (2.5, 7.2)/33 μM, respectively (IC50 101 μM for acarbose and 79 μM for 1-deoxynojirimycin).

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