2. Academic Validation
  3. Bioactive Terpenoids from Salvia plebeia: Structures, NO Inhibitory Activities, and Interactions with iNOS

Bioactive Terpenoids from Salvia plebeia: Structures, NO Inhibitory Activities, and Interactions with iNOS

  • J Nat Prod. 2016 Nov 23;79(11):2924-2932. doi: 10.1021/acs.jnatprod.6b00733.
Jing Xu,  Meicheng Wang,  Xiaocong Sun,  Quanhui Ren,  Xiangrong Cao,  Shen Li,  Guochen Su,  Muhetaer Tuerhong 1,  Dongho Lee 2,  Yasushi Ohizumi 3,  Mark Bartlam,  Yuanqiang Guo
Affiliations

Affiliations

  • 1 College of Chemistry and Environmental Sciences, Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashgar University , Kashgar 844000, People's Republic of China.
  • 2 Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University , Seoul 02841, Republic of Korea.
  • 3 Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka , Shizuoka, Japan.
PMID: 27933899 DOI: 10.1021/acs.jnatprod.6b00733
Abstract

A phytochemical investigation to obtain new NO inhibitors resulted in the identification of six new (1-6) and four known (7-10) Terpenoids from Salvia plebeia. Compounds 1 and 2 are new Diterpenoids, 3-5 are new meroditerpenoids, 6-9 are sesquiterpenoids, and 10 is a known meroditerpenoid. The structures of these isolates were determined by routine NMR experiments and X-ray diffraction, as well as the electronic circular dichroism spectra. Compounds 1-4 are Diterpenoids carrying an oxygen bridge, and 6 is a rare copane-type sesquiterpenoid with a bridged tricyclic framework. The isolates inhibited NO generation induced by lipopolysaccharide in BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed interactions of bioactive compounds with the iNOS protein.

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