2. Academic Validation
  3. Kmeriol and other aromatic constituents of Kmeria duperreana

Kmeriol and other aromatic constituents of Kmeria duperreana

  • Pharm Res. 1989 Jul;6(7):637-40. doi: 10.1023/a:1015969902200.
X P Dong 1,  I O Mondranondra,  C T Che,  H S Fong,  N R Farnsworth
Affiliations

Affiliation

  • 1 Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60680.
PMID: 2798315 DOI: 10.1023/a:1015969902200
Abstract

The CHCl3-soluble fraction of a crude extract of Kmeria duperreana exhibited cytotoxic activity when tested in both KB and P388 tumor-cell cultures. Bioassay-directed fractionation led to the isolation of a cytotoxic alkaloid, liriodenine (1). Other constituents obtained from the extract included scopoletin (2), (-)-3,4,5-trimethoxyphenyl beta-D-glucopyranoside (3), (+)-syringaresinol beta-D-glucopyranoside (4), and a new phenylpropanol, kmeriol (5), whose chemical structure was established through spectroscopic analysis.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-118192
    Natural Product