2. Academic Validation
  3. ent-Strobane and ent-Pimarane Diterpenoids from Siegesbeckia pubescens

ent-Strobane and ent-Pimarane Diterpenoids from Siegesbeckia pubescens

  • J Nat Prod. 2017 Jan 27;80(1):19-29. doi: 10.1021/acs.jnatprod.6b00150.
Jianbin Wang 1,  Hongquan Duan 2,  Yi Wang 1,  Bowen Pan 1,  Chun Gao 1,  Chunyan Gai 1,  Qiong Wu 1,  Hongzheng Fu 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University , Beijing 100191, People's Republic of China.
  • 2 Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University , Tianjin 300070, People's Republic of China.
PMID: 28009521 DOI: 10.1021/acs.jnatprod.6b00150
Abstract

Two strobane Diterpenoids, strobols A (1) and B (2), 15 new pimarane Diterpenoids (3-6 and 8-18), and the known compounds kirenol (19), darutigenol (20), and ent-2β,15,16,19-tetrahydroxypimar-8(14)-ene (7) were isolated from the aerial parts of Siegesbeckia pubescens Makino. The structures of the new compounds were established based on the interpretation of HRESIMS and NMR analysis. The configurations of 1, 6, and 17 were confirmed by X-ray crystallographic data. Compounds 3, 5, and 11 inhibited the migration of MB-MDA-231 breast Cancer cells induced by the chemokine epithelial growth factor, with IC50 values of 4.26, 3.45, and 9.70 μM, respectively.

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