2. Academic Validation
  3. The promiscuous ectonucleotidase NPP1: molecular insights into substrate binding and hydrolysis

The promiscuous ectonucleotidase NPP1: molecular insights into substrate binding and hydrolysis

  • Biochim Biophys Acta Gen Subj. 2017 Mar;1861(3):603-614. doi: 10.1016/j.bbagen.2016.12.019.
Vigneshwaran Namasivayam 1,  Sang-Yong Lee 1,  Christa E Müller 2
Affiliations

Affiliations

  • 1 PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical Chemistry I, University of Bonn, Germany.
  • 2 PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical Chemistry I, University of Bonn, Germany. Electronic address: christa.mueller@uni-bonn.de.
PMID: 28011303 DOI: 10.1016/j.bbagen.2016.12.019
Keywords

2′,3″-cGAMP; Cancer immunotherapy; Nucleotide pyrophosphatase 1; Substrate promiscuity; cAMP.

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