2. Academic Validation
  3. Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model

Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model

  • World J Mens Health. 2017 Apr;35(1):43-50. doi: 10.5534/wjmh.2017.35.1.43.
Hyong Woo Moon 1,  Jung Woo Park 1,  Kyu Won Lee 1,  Hyun Cheol Jeong 1,  Jin Bong Choi 1,  Sae Woong Choi 1,  Woong Jin Bae 1 2,  Hyuk Jin Cho 1,  U Syn Ha 1,  Sung Hoo Hong 1,  Jeong Ho Geum 3,  Seong Bin Hong 3,  Sae Woong Kim 1 4
Affiliations

Affiliations

  • 1 Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 2 Catholic Integrative Medicine Research Institute, The Catholic University of Korea, Seoul, Korea.
  • 3 Biomix Inc., Goyang, Korea.
  • 4 Catholic Integrative Medicine Research Institute, The Catholic University of Korea, Seoul, Korea. ksw1227@catholic.ac.kr.
PMID: 28064475 DOI: 10.5534/wjmh.2017.35.1.43
Abstract

Purpose: This study investigated the effect of goji (Lycium chinense Mill.) on erectile dysfunction in old-aged rats.

Materials and methods: Twenty-four 18-month-old male Sprague-Dawley rats (defined as old-aged rats) were used. Treatment groups contained eight rats each: a control group, goji extract of 150 mg/kg/day group, and goji extract of 300 mg/kg/day group. Treatment was by orogastric tube once daily for 6 weeks. After 6 weeks of treatment, testes weight, serum testosterone, superoxide dismutase, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, intracavernous pressure/mean arterial pressure, and histological changes were examined.

Results: Treatments with goji extracts increased serum testosterone level, increased the expression of endothelial NO Synthase, neuronal NO Synthase, and cGMP, improved the oxidative stress marker, and decreased corporal fibrosis.

Conclusions: Our results indicate that goji extract may have a positive effect on erectile dysfunction via its antioxidant effects.

Keywords

Antioxidants; Erectile dysfunction; Testosterone.

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