2. Academic Validation
  3. Primary lateral sclerosis in a child

Primary lateral sclerosis in a child

  • Neurology. 1989 Nov;39(11):1530-2. doi: 10.1212/wnl.39.11.1530.
M L Grunnet 1,  C Leicher,  A Zimmerman,  E Zalneraitis,  M Barwick
Affiliations

Affiliation

  • 1 Department of Neurology, University of Connecticut Health Center, Farmington 06032.
PMID: 2812336 DOI: 10.1212/wnl.39.11.1530
Abstract

Primary lateral sclerosis (PLS), previously undescribed in children, is characterized by a spastic motor deterioration and pathologic demonstration of corticospinal tract degeneration. We report an infant who, before 12 months of age, developed a progressive motor disease characterized by generalized spasticity. He died at 47 months, and neuropathologic examination revealed only corticospinal tract degeneration. We conclude that this child had typical clinical and pathologic findings for PLS.

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