2. Academic Validation
  3. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogon japonicus

Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogon japonicus

  • Phytochemistry. 2017 Apr;136:125-132. doi: 10.1016/j.phytochem.2017.01.006.
Lun Wang 1,  Xi-Lan Jiang 2,  Wen-Ming Zhang 3,  Fu Li 4,  Ashfaq-Ahmad Khan 5,  Xin Liu 6,  Kai Yu 3,  Ming-Kui Wang 7
Affiliations

Affiliations

  • 1 School of Pharmacy and Bioengineering, Chengdu University, Chengdu, 610106, China; Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China.
  • 2 Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China.
  • 3 School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610013, China.
  • 4 School of Pharmacy and Bioengineering, Chengdu University, Chengdu, 610106, China; Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China. Electronic address: lifu@cib.ac.cn.
  • 5 Department of Chemistry, Women University of Azad Jammu and Kashmir, Bagh, 12500, Pakistan.
  • 6 Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing, 100026, China.
  • 7 School of Pharmacy and Bioengineering, Chengdu University, Chengdu, 610106, China; Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China. Electronic address: wangmk@cib.ac.cn.
PMID: 28139298 DOI: 10.1016/j.phytochem.2017.01.006
Abstract

Phytochemical investigation of the tubers of Ophiopogon japonicus led to the isolation of five previously undescribed steroidal saponins, ophiojaponins A-E, together with twelve known ones. The structures of these isolated compounds were elucidated by detailed spectroscopic analyses and chemical methods. Ophiojaponins A-C are rare naturally occurring C29 steroidal glycosides possessing a homo-cholestane skeleton with an aromatized ring E. Ruscogenin 1-O-α-L-rhamnopyranosyl-(1 → 2)-4-O-sulfo-β-D-fucopyranosido-3-O-β-D-glucopyranoside was isolated as single component and its full spectroscopic data was reported for the first time. The isolated steroidal saponins were evaluated for their cytotoxicities against two human tumor cell lines MG-63 and SNU387. Among them, five known spirostane-type glycosides showed cytotoxic activity against both MG-63 and SNU387 cell lines with IC50 values ranging from 0.76 to 27.0 μM.

Keywords

C(27)-steroidal saponins; C(29)-steroidal saponins; Cytotoxic activity; Liliaceae; Ophiopogon japonicus.

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