2. Academic Validation
  3. Klyflaccisteroids K-M, bioactive steroidal derivatives from a soft coral Klyxum flaccidum

Klyflaccisteroids K-M, bioactive steroidal derivatives from a soft coral Klyxum flaccidum

  • Bioorg Med Chem Lett. 2017 Mar 1;27(5):1220-1224. doi: 10.1016/j.bmcl.2017.01.060.
Yi-Ying Tsai 1,  Chiung-Yao Huang 1,  Wan-Ru Tseng 1,  Pei-Lun Chiang 2,  Tsong-Long Hwang 3,  Jui-Hsin Su 4,  Ping-Jyun Sung 4,  Chang-Feng Dai 5,  Jyh-Horng Sheu 6
Affiliations

Affiliations

  • 1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
  • 2 Department of Biochemistry, University of Toronto, Toronto M5G2R3, Canada.
  • 3 Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan; Department of Cosmetic Science and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.
  • 4 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.
  • 5 Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan.
  • 6 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan; Graduate Institute of Natural Products, School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, Taiwan. Electronic address: sheu@mail.nsysu.edu.tw.
PMID: 28159416 DOI: 10.1016/j.bmcl.2017.01.060
Abstract

New Steroids, klyflaccisteroids K-M (1-3), were isolated from a soft coral Klyxum flaccidum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Klyflaccisteroid K (1) is the unique 9,11-secosteroid with a 5,8-epidioxy-9-ene functional group. Klyflaccisteroid L (2) has an unusual 11-norsteroid skeleton and is the first example of 11-oxasteroid isolated from natural sources. Cytotoxicity assay showed that 1 and 3 possessed moderate to weak cytotoxicity against these Cancer cells. Compound 1 was also found to display significant anti-inflammatory activity of suppressing superoxide anion generation (O2-) and Elastase release, and compound 3 was found to show notable anti-inflammatory activity toward inhibition of elasstase release, too.

Keywords

Anti-inflammatory activity; Cytotoxicity; Klyflaccisteroid; Klyxum flaccidum; Steroid.

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