2. Academic Validation
  3. Adamantane in Drug Delivery Systems and Surface Recognition

Adamantane in Drug Delivery Systems and Surface Recognition

  • Molecules. 2017 Feb 16;22(2):297. doi: 10.3390/molecules22020297.
Adela Štimac 1,  Marina Šekutor 2,  Kata Mlinarić-Majerski 3,  Leo Frkanec 4,  Ruža Frkanec 5
Affiliations

Affiliations

  • 1 University of Zagreb, Centre for Research and Knowledge Transfer in Biotechnology, Rockefellerova 10, 10000 Zagreb, Croatia. astimac@unizg.hr.
  • 2 Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia. marina.sekutor@irb.hr.
  • 3 Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia. majerski@irb.hr.
  • 4 Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia. frkanec@irb.hr.
  • 5 University of Zagreb, Centre for Research and Knowledge Transfer in Biotechnology, Rockefellerova 10, 10000 Zagreb, Croatia. rfrkanec@unizg.hr.
PMID: 28212339 DOI: 10.3390/molecules22020297
Abstract

The adamantane moiety is widely applied in design and synthesis of new Drug Delivery systems and in surface recognition studies. This review focuses on liposomes, cyclodextrins, and dendrimers based on or incorporating adamantane derivatives. Our recent concept of adamantane as an anchor in the lipid bilayer of liposomes has promising applications in the field of targeted Drug Delivery and surface recognition. The results reported here encourage the development of novel adamantane-based structures and self-assembled supramolecular systems for basic chemical investigations as well as for biomedical application.

Keywords

adamantane; cyclodextrins; dendrimers; liposomes; surface recognition; targeted drug delivery.

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