2. Academic Validation
  3. Antibacterial Nerol Cinnamates from the Australian Plant Eremophila longifolia

Antibacterial Nerol Cinnamates from the Australian Plant Eremophila longifolia

  • J Nat Prod. 2017 Apr 28;80(4):1178-1181. doi: 10.1021/acs.jnatprod.6b00888.
Savithri Galappathie 1,  David J Edwards 2,  Alysha G Elliott 2,  Matthew A Cooper 2,  Enzo A Palombo 1,  Mark S Butler 2,  Peter J Mahon 1
Affiliations

Affiliations

  • 1 Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology , Hawthorn 3122, Victoria, Australia.
  • 2 Institute for Molecular Bioscience, University of Queensland , St Lucia 4072, Queensland, Australia.
PMID: 28257200 DOI: 10.1021/acs.jnatprod.6b00888
Abstract

Two new antimicrobial agents, neryl ferulate (1) and neryl p-coumarate (2), were identified using bioassay-guided isolation from the leaves of Eremophila longifolia, which is a medicinal plant used by some Australian Aboriginal communities. Although gradual autoxidation of the nerol subunit hindered the initial attempts to purify and characterize 1 and 2, it was found that the autoxidation could be stopped through storage under argon at -20 °C. Biological evaluation showed that neryl ferulate (1) had moderate activity against various Gram-positive bacteria, while neryl p-coumarate (2) was active only against Enterococcus faecium.

Figures