2. Academic Validation
  3. Cytotoxic dammarane-type triterpenoids from the leaves of Viburnum sambucinum

Cytotoxic dammarane-type triterpenoids from the leaves of Viburnum sambucinum

  • Bioorg Med Chem Lett. 2017 Apr 15;27(8):1665-1669. doi: 10.1016/j.bmcl.2017.03.014.
Thanh Tra Nguyen 1,  Bich Ngan Truong 2,  Huong Doan Thi Mai 3,  Marc Litaudon 4,  Van Hung Nguyen 3,  Thao Do Thi 5,  Van Minh Chau 3,  Van Cuong Pham 6
Affiliations

Affiliations

  • 1 Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 2 Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: tbngan1977@yahoo.com.
  • 3 Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 4 Institut de Chimie des Substances Naturelles, CNRS-ICSN, UPR 2301, Univ. Paris-Sud, 91198 Gif-sur-Yvette, France.
  • 5 Institute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 6 Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: phamvc@imbc.vast.vn.
PMID: 28318944 DOI: 10.1016/j.bmcl.2017.03.014
Abstract

Four new dammarane-type triterpenoids (1-4) and twelve known compounds (5-16) were isolated from the leaves of Viburnum sambucinum Reinw. ex Blume. Their structures were determined by spectral data analysis, including MS and 2D NMR. Cytotoxic activity evaluation in vitro against four Cancer cell lines (KB, LU-1, HepG2 and MCF7) suggested that the octanor-dammarane derivatives were the main cytotoxic components of the leaves of V. sambucinum.

Keywords

Adoxaceae; Caprifoliaceae; Dammarane; Viburnum; Vibusambucin.

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