2. Academic Validation
  3. Monoterpenoid indole alkaloids from Alstonia mairei and their cytotoxicity

Monoterpenoid indole alkaloids from Alstonia mairei and their cytotoxicity

  • J Asian Nat Prod Res. 2017 Jun;19(6):550-556. doi: 10.1080/10286020.2017.1313242.
Ting-Liang Yan 1,  Dun-Xin Han 2,  Jiang Hu 3,  Xiao-Yun Huang 1,  Hong-Kun Wang 4
Affiliations

Affiliations

  • 1 a Department of Basic Medicine , Qujing Medical College , Qujing 655000 , China.
  • 2 b Department of Spine Surgery , 107th Hospital of People's Liberation Army , Yantai , China.
  • 3 c College of Biological Resources and Environment Science , Qujing Normal University , Qujing 655011 , China.
  • 4 d Department of Plastic and Burns Surgery , Fujian Dongfang Hospital, Xiamen University , Fuzhou 350025 , China.
PMID: 28393571 DOI: 10.1080/10286020.2017.1313242
Abstract

Phytochemical investigation on the 70% ethanol extract of the leaves of Alstonia mairei resulted in the isolation of three new monoterpenoid Indole Alkaloids, alstomairines A-C (1-3), along with one known compound, alpneumine A (4). Structural elucidation of all the compounds was accomplished by spectral methods such as 1D and 2D NMR, IR, UV, and HRESIMS. The isolated compounds were tested in vitro for cytotoxic activities against four osteosarcoma cell lines. Consequently, Alkaloids 2 and 3 exhibited cytotoxic activities for all tested tumor cell lines with IC50 values from 9.2 to 13.0 μM.

Keywords

Alstonia mairei; Apocynaceae; cytotoxicity; monoterpenoid indole alkaloids.

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