2. Academic Validation
  3. Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues

Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues

  • J Nat Prod. 2017 May 26;80(5):1339-1346. doi: 10.1021/acs.jnatprod.6b00941.
Marianna Carbone 1,  M Letizia Ciavatta 1,  Véronique Mathieu 2,  Aude Ingels 2,  Robert Kiss 2,  Paola Pascale 1,  Ernesto Mollo 1,  Nicon Ungur 3,  Yue-Wei Guo 4,  Margherita Gavagnin 1
Affiliations

Affiliations

  • 1 Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB) , Via Campi Flegrei, 34, 80078 Pozzuoli (Na), Italy.
  • 2 Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles (ULB) , Campus de la Plaine, Boulevard du Triomphe, 1050 Brussels, Belgium.
  • 3 Institute of Chemistry, Moldova Academy of Sciences , Academiei str. 3, MD-2028 Chisinau, Republic of Moldova.
  • 4 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, P.R. China.
PMID: 28406636 DOI: 10.1021/acs.jnatprod.6b00941
Abstract

A new diacylguanidine, actinofide (1), has been isolated from the marine mollusk Actinocyclus papillatus. The structure, exhibiting a guanidine moiety acylated by two terpenoid acid units, has been established by spectroscopic methods and secured by synthesis. Following this, a series of structural analogues have been synthesized using the same procedure. All of the compounds have been evaluated in vitro for the growth inhibitory activity against a variety of Cancer cell lines.

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