2. Academic Validation
  3. Chemical constituents from the whole plants of Pilea cavaleriei Levl subsp. cavaleriei

Chemical constituents from the whole plants of Pilea cavaleriei Levl subsp. cavaleriei

  • Fitoterapia. 2017 Jun:119:100-107. doi: 10.1016/j.fitote.2017.04.010.
Yong Zhou 1,  Ling-Yu Li 2,  Heng-Chun Ren 3,  Ri-Dong Qin 3,  Qin Li 3,  Peng-Fei Tu 3,  Gui-Fang Dou 4,  Qing-Ying Zhang 5,  Hong Liang 6
Affiliations

Affiliations

  • 1 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China; State Key Laboratory of Drug Metabolism, Laboratory of Hematological Pharmacology, Beijing Institute of Transfusion Medicine, Beijing 100850, PR China.
  • 2 Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, PR China.
  • 3 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
  • 4 State Key Laboratory of Drug Metabolism, Laboratory of Hematological Pharmacology, Beijing Institute of Transfusion Medicine, Beijing 100850, PR China.
  • 5 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China. Electronic address: qyzhang@bjmu.edu.cn.
  • 6 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China. Electronic address: lianghong@bjmu.edu.cn.
PMID: 28408268 DOI: 10.1016/j.fitote.2017.04.010
Abstract

Three new sesquiterpene glycosides (1-3), three new glycerol glycosides (4-6), two new Alkaloids (7-8), together with seven known compounds (9-15) all of which were isolated from the genus Pilea for the first time, were isolated from the whole Plants of Pilea cavaleriei Levl subsp. cavaleriei. Their structures were determined by extensive spectroscopic techniques and chemical methods. The cytotoxic activity of the isolated compounds was evaluated against four Cancer cell lines, and none of the tested compounds caused a significant reduction of the cell number.

Keywords

Alkaloids; Cytotoxic activity; Glycerol glycosides; Pilea cavaleriei Levl subsp. cavaleriei; Sesquiterpene glycosides.

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