2. Academic Validation
  3. Lactone Derivatives Produced by a Phaeoacremonium sp., an Endophytic Fungus from Senna spectabilis

Lactone Derivatives Produced by a Phaeoacremonium sp., an Endophytic Fungus from Senna spectabilis

  • J Nat Prod. 2017 May 26;80(5):1674-1678. doi: 10.1021/acs.jnatprod.5b00828.
Geraldo H Silva 1,  Maria L Zeraik 2,  Camila M de Oliveira 3,  Helder L Teles 4,  Henrique C Trevisan 2,  Ludwig H Pfenning 5,  Camila P Nicolli 5,  Maria C M Young 6,  Yvonne P Mascarenhas 7,  Lucas M Abreu 8,  Amanda C Saraiva 9,  Alexandra I Medeiros 9,  Vanderlan da S Bolzani 2,  Angela R Araujo 2
Affiliations

Affiliations

  • 1 Instituto de Ciências Exatas e Tecnológicas, Universidade Federal de Viçosa , Rio Paranaíba, Minas Gerais 38810-000, Brazil.
  • 2 Department of Organic Chemistry, São Paulo State University (Unesp), Chemistry Institute, Araraquara, São Paulo 14800-900, Brazil.
  • 3 Instituto de Ciências Exatas e Tecnologia, Universidade Federal do Amazonas , Itacoatiara, Amazonas 69103-128, Brazil.
  • 4 Instituto de Ciências Exatas e Naturais, Universidade Federal de Mato Grosso , Rondonópolis, Mato Grosso 78735-901, Brazil.
  • 5 Departamento de Fitopatologia, Universidade Federal de Lavras , Lavras, Minas Gerais 37200-000, Brazil.
  • 6 Seção de Fisiologia e Bioquímica de Plantas, Instituto de Botânica , São Paulo, São Paulo 04301-902, Brazil.
  • 7 Instituto de Física de São Carlos, Universidade de São Paulo , São Carlos, São Paulo 13560-970, Brazil.
  • 8 Departamento de Fitopatologia, Universidade Federal de Viçosa , Viçosa, Minas Gerais 36570000, Brazil.
  • 9 São Paulo State University (Unesp), School of Pharmaceutical Sciences, Araraquara, São Paulo 14801-902, Brazil.
PMID: 28425292 DOI: 10.1021/acs.jnatprod.5b00828
Abstract

Three new isoaigialones, A, B, and C (1-3), along with aigialone (4), were isolated from the crude EtOAc extract of a Phaeoacremonium sp., an endophytic fungus obtained from the leaves of Senna spectabilis. The structures of these compounds were elucidated based on the analysis of spectroscopic data. Compounds 2 and 4 were active against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum. This is the first report of metabolites produced by an Phaeoacremonium sp., associated with S. spectabilis.

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