2. Academic Validation
  3. An Approach to the Core of Lactonamycin

An Approach to the Core of Lactonamycin

  • Org Lett. 2017 May 19;19(10):2533-2535. doi: 10.1021/acs.orglett.7b00902.
Philip J Parsons 1,  Daniel R Jones 1,  Lee J Walsh 1,  Lewis A T Allen 1,  Ada Onwubiko 1,  Lewis Preece 2,  Johnathan Board 2,  Andrew J P White 1
Affiliations

Affiliations

  • 1 Department of Chemistry, Imperial College London , South Kensington, London SW7 2AZ, U.K.
  • 2 Department of Chemistry, University of Sussex , Falmer, Brighton BN1 9RH, U.K.
PMID: 28445072 DOI: 10.1021/acs.orglett.7b00902
Abstract

A cascade reaction has been developed for the synthesis of lactonamycin. In this paper, we demonstrate that a transition-metal-free thermal ene-diyne cyclization can be used for the construction of the entire core of the Antibiotic lactonamycin and Anticancer agent lactonamycin Z.

Figures
Products