2. Academic Validation
  3. Scalemic Caged Xanthones Isolated from the Stem Bark Extract of Garcinia propinqua

Scalemic Caged Xanthones Isolated from the Stem Bark Extract of Garcinia propinqua

  • J Nat Prod. 2017 May 26;80(5):1658-1667. doi: 10.1021/acs.jnatprod.7b00240.
Teerayut Sriyatep 1,  Raymond J Andersen 2,  Brian O Patrick 2,  Stephen G Pyne 3,  Chatchai Muanprasat 4,  Sawinee Seemakhan 5,  Suparerk Borwornpinyo 5,  Surat Laphookhieo 1
Affiliations

Affiliations

  • 1 Natural Products Research Laboratory, School of Science, Mae Fah Luang University , Chiang Rai 57100, Thailand.
  • 2 Department of Chemistry and Department of Earth, Ocean, and Atmospheric Sciences, University of British Columbia , 2036 Main Mall, Vancouver, British Columbia, Canada V6T 1Z1.
  • 3 School of Chemistry, University of Wollongong , Wollongong, New South Wales 2522, Australia.
  • 4 Department of Physiology, Faculty of Science, Mahidol University , Rajathevi, Bangkok 10400, Thailand.
  • 5 Excellent Center for Drug Discovery, Faculty of Science, Mahidol University , Rajathevi, Bangkok 10400, Thailand.
PMID: 28489373 DOI: 10.1021/acs.jnatprod.7b00240
Abstract

Seven new caged Xanthones, doitunggarcinones E-K (1-7), all as scalemic mixtures and 10 known compounds (8-17), were isolated from the stem bark extract of Garcinia propinqua. The structures were elucidated on the basis of spectroscopic methods. The separation of the enantiomers of 1-6 was achieved by semipreparative chiral HPLC. The absolute configuration of compound (+)-1 was determined by single-crystal X-ray crystallographic analysis using Cu Kα radiation. The absolute configurations of the Other related compounds were determined from comparisons of their ECD spectra with that of compound (+)-1. Compounds (-)-6 and 7 showed cytotoxicity against a colon Cancer cell line with IC50 values of 14.23 and 23.95 μM, respectively.

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