Alkaloids from aerial parts of Houttuynia cordata and their anti-inflammatory activity

Bioorg Med Chem Lett. 2017 Jun 15;27(12):2807-2811. doi: 10.1016/j.bmcl.2017.04.072.

Jongmin Ahn ¹, Hee-Sung Chae ², Young-Won Chin ², Jinwoong Kim ³

Affiliations

1 College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
2 College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Gyeonggi-do 10326, Republic of Korea.
3 College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: jwkim@snu.ac.kr.

PMID: 28499733 DOI: 10.1016/j.bmcl.2017.04.072

Abstract

New Alkaloids, houttuynamide B and C (1, 2) and houttuycorine (14), were isolated from the aerial parts of Houttuynia cordata Thunb. in addition to eighteen known Alkaloids. Their structures were elucidated through extensive spectroscopic analysis. All the isolates were tested for their inhibitory activity against NO production in RAW 264.7 cells stimulated by LPS. Of the tested compounds, compound 15 showed the most potent anti-inflammatory activity with an IC₅₀ value of 8.7μM.

Keywords

Alkaloids; Anti-inflammatory; Benzamides; Houttuynia cordata; β-Carboline alkaloid.

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