2. Academic Validation
  3. C-geranylated flavanones from YingDe black tea and their antioxidant and α-glucosidase inhibition activities

C-geranylated flavanones from YingDe black tea and their antioxidant and α-glucosidase inhibition activities

  • Food Chem. 2017 Nov 15;235:227-233. doi: 10.1016/j.foodchem.2017.05.034.
Hua Zhou 1,  Hai-Mei Li 2,  Yang-Min Du 2,  Ri-An Yan 2,  Shi-Yi Ou 2,  Tian-Feng Chen 3,  Yong Wang 2,  Li-Xin Zhou 3,  Liang Fu 2
Affiliations

Affiliations

  • 1 Department of Food Science and Engineering, Jinan University, Guangzhou 510632, Guangdong, China. Electronic address: zhhua-1@163.com.
  • 2 Department of Food Science and Engineering, Jinan University, Guangzhou 510632, Guangdong, China.
  • 3 Department of Chemistry, Jinan University, Guangzhou 510632, Guangdong, China.
PMID: 28554631 DOI: 10.1016/j.foodchem.2017.05.034
Abstract

YingDe black tea is produced from crude tea prepared from leaves of Camellia sinensis var. assamica. In this work, we isolated and identified five novel flavanones, namely, amelliaone A-E (1-5), along with seven known compounds 6-12 from the ethanol extract of YingDe black tea. The structures of these five novel phenolic compounds were determined using extensive 1D and 2D nuclear magnetic resonance spectroscopy experiments. The compounds were further evaluated for antioxidant, α-glucosidase inhibitory, and cytotoxic activities. Compound 1 exhibited higher α-glucosidase inhibitory activity with a half-maximum inhibitory concentration value (IC50) of 10.2µM compared with acarbose (18.2µM).

Keywords

(−)-Epicatechin (PubChem CID: 72276); (−)-Gallocatechin gallate (PubChem CID: 199472); Amentoflavone (PubChem CID: 5281600); Apigenin (PubChem CID: 5280443); Camellia var. assamica; Epigallocatechin gallate (PubChem CID: 65064); Flavanone; Gallic acid (PubChem CID: 370); Quercetin (PubChem CID: 5280343); YingDe black tea; α-Glucosidase inhibitory activity.

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