2. Academic Validation
  3. Trichoderpyrone, a Unique Polyketide Hybrid with a Cyclopentenone-Pyrone Skeleton from the Plant Endophytic Fungus Trichoderma gamsii

Trichoderpyrone, a Unique Polyketide Hybrid with a Cyclopentenone-Pyrone Skeleton from the Plant Endophytic Fungus Trichoderma gamsii

  • J Nat Prod. 2017 Jun 23;80(6):1944-1947. doi: 10.1021/acs.jnatprod.7b00190.
Lin Chen 1 2,  Shu-Bin Niu 3,  Li Li 4,  Gang Ding 1,  Meng Yu 1,  Gui-Shan Zhang 5,  Meng-Hua Wang 1,  Lu-Ying Li 1,  Tao Zhang 1,  Hong-Mei Jia 1,  Hong-Wu Zhang 1,  Hai Shang 1,  Xing-Zhong Liu 6,  Zhong-Mei Zou 1
Affiliations

Affiliations

  • 1 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100193, People's Republic of China.
  • 2 Zhengzhou Key Laboratory of Medicinal Resources Research, Institute of Nanostructured Functional Materials, Huanghe Science and Technology College , Zhengzhou, Henan 450006, People's Republic of China.
  • 3 School of Biological Medicine, Beijing City University , Beijing 450046, People's Republic of China.
  • 4 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica , Beijing 100050, People's Republic of China.
  • 5 Key Laboratory of Microbial Resources Collection and Preservation, Ministry of Agriculture, Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences , Beijing 100081, People's Republic of China.
  • 6 State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100090, People's Republic of China.
PMID: 28571311 DOI: 10.1021/acs.jnatprod.7b00190
Abstract

Trichoderpyrone (1), a unique polyketide with a cyclopentenone-pyrone hybrid skeleton, was isolated from the plant endophytic fungus Trichoderma gamsii. The structure of 1 was determined by detailed analysis of NMR data together with comparison of chemical shift values of similar fragments. The relative and absolute configurations were established by NOESY correlations and CD experiment. Trichoderpyrone (1) displayed weak cytotoxic activities against A549, HepG2, and HeLa Cancer cell lines. 1 might originate from a hybrid biosynthetic pathway through two nonreduced (NR) polyketide megasynthetases.

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