2. Academic Validation
  3. Bioactive new withanolides from the cultured soft coral Sinularia brassica

Bioactive new withanolides from the cultured soft coral Sinularia brassica

  • Bioorg Med Chem Lett. 2017 Aug 1;27(15):3267-3271. doi: 10.1016/j.bmcl.2017.06.029.
Chiung-Yao Huang 1,  Atallah F Ahmed 2,  Jui-Hsin Su 3,  Ping-Jyun Sung 4,  Tsong-Long Hwang 5,  Pei-Lun Chiang 6,  Chang-Feng Dai 7,  Chih-Chuang Liaw 1,  Jyh-Horng Sheu 8
Affiliations

Affiliations

  • 1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
  • 2 Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • 3 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan; Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
  • 4 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.
  • 5 Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
  • 6 Department of Biochemistry, University of Toronto, Toronto M5G2R3, Canada.
  • 7 Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan.
  • 8 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan. Electronic address: sheu@mail.nsysu.edu.tw.
PMID: 28648460 DOI: 10.1016/j.bmcl.2017.06.029
Abstract

Continuing study of the ethyl acetate (EtOAc) extract of the cultured soft coral Sinularia brassica afforded five new withanolides, sinubrasolides H-L (1-5). The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxicities of new compounds 1-5 and a known compound sinubrasolide A (6) against the proliferation of a limited panel of Cancer cell lines were assayed. The anti-inflammatory activities of compounds 1-6 were evaluated by measuring their ability to suppress N-formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and Elastase release in human neutrophils.

Keywords

Anti-inflammatory activity; Cytotoxicity; Sinularia brassica; Soft coral; Withanolide.

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