2. Academic Validation
  3. Flavonoid glycosides from Barringtonia acutangula

Flavonoid glycosides from Barringtonia acutangula

  • Bioorg Med Chem Lett. 2017 Aug 15;27(16):3776-3781. doi: 10.1016/j.bmcl.2017.06.066.
Le Thi Vien 1,  Quach Thi Thanh Van 2,  Tran Thi Hong Hanh 1,  Phan Thi Thanh Huong 1,  Nguyen Thi Kim Thuy 3,  Nguyen The Cuong 4,  Nguyen Hai Dang 1,  Nguyen Van Thanh 1,  Nguyen Xuan Cuong 5,  Nguyen Hoai Nam 1,  Phan Van Kiem 1,  Chau Van Minh 6
Affiliations

Affiliations

  • 1 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 2 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Viet Tri University of Industry, 09 Tien Son, Viet Tri, Phutho, Viet Nam.
  • 3 Viet Tri University of Industry, 09 Tien Son, Viet Tri, Phutho, Viet Nam.
  • 4 Institute of Ecology and Biological Resources, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 5 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: cuongnx@imbc.vast.vn.
  • 6 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: cvminh@vast.vn.
PMID: 28688956 DOI: 10.1016/j.bmcl.2017.06.066
Abstract

Using various chromatographic separation techniques, ten flavonoid glycosides, including six new compounds namely barringosides A-F (1-6), were isolated from a methanol extract of the Barringtonia acutangula leaves. The structure elucidation was confirmed by spectroscopic analyses, including 1D and 2D NMR, and HR ESI MS. Their inhibitory effects on LPS-induced NO production in RAW264.7 cells were also evaluated. Among the isolated compounds, quercetin 3-O-β-d-(6-p-hydroxybenzoyl)galactopyranoside (9) showed significant effect with an IC50 of 20.00±1.68µM. This is the first report of these flavonoid glycosides from Barringtonia genus and their inhibition on LPS-induced NO production in RAW264.7 cells was reported here for the first time.

Keywords

Barringtonia acutangula; Flavonoid glycoside; Lecythidaceae; NO production.

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