2. Academic Validation
  3. The medicinal chemistry of Chikungunya virus

The medicinal chemistry of Chikungunya virus

  • Bioorg Med Chem. 2017 Aug 15;25(16):4219-4244. doi: 10.1016/j.bmc.2017.06.049.
Edeildo F da Silva-Júnior 1,  Giovanni O Leoncini 2,  Érica E S Rodrigues 3,  Thiago M Aquino 4,  João X Araújo-Júnior 5
Affiliations

Affiliations

  • 1 Laboratory of Medicinal Chemistry, Nursing and Pharmacy School, Federal University of Alagoas, Lourival Melo Motta Avenue, Tabuleiro dos Martins, 57072-900 Maceió, Brazil; Chemistry and Biotechnology Institute, Federal University of Alagoas, Lourival Melo Motta Avenue, Tabuleiro dos Martins, 57072-900 Maceió, Brazil. Electronic address: edeildo.junior@esenfar.ufal.br.
  • 2 Laboratory of Medicinal Chemistry, Nursing and Pharmacy School, Federal University of Alagoas, Lourival Melo Motta Avenue, Tabuleiro dos Martins, 57072-900 Maceió, Brazil; Chemistry and Biotechnology Institute, Federal University of Alagoas, Lourival Melo Motta Avenue, Tabuleiro dos Martins, 57072-900 Maceió, Brazil.
  • 3 Laboratory of Medicinal Chemistry, Nursing and Pharmacy School, Federal University of Alagoas, Lourival Melo Motta Avenue, Tabuleiro dos Martins, 57072-900 Maceió, Brazil.
  • 4 Chemistry and Biotechnology Institute, Federal University of Alagoas, Lourival Melo Motta Avenue, Tabuleiro dos Martins, 57072-900 Maceió, Brazil.
  • 5 Laboratory of Medicinal Chemistry, Nursing and Pharmacy School, Federal University of Alagoas, Lourival Melo Motta Avenue, Tabuleiro dos Martins, 57072-900 Maceió, Brazil; Chemistry and Biotechnology Institute, Federal University of Alagoas, Lourival Melo Motta Avenue, Tabuleiro dos Martins, 57072-900 Maceió, Brazil. Electronic address: jotaaraujo2004@gmail.com.
PMID: 28689975 DOI: 10.1016/j.bmc.2017.06.049
Abstract

Arthropod-borne viruses (arboviruses) are an important threat to human and animal health globally. Among these, zoonotic diseases account for billions of cases of human illness and millions of deaths every year, representing an increasing public health problem. Chikungunya virus belongs to the genus Alphavirus of the family Togariridae, and is transmitted mainly by the bite of female mosquitoes of the Aedes aegypti and/or A. albopictus species. The focus of this review will be on the medicinal chemistry of Chikungunya virus, including synthetic and Natural Products, as well as rationally designed compounds.

Keywords

Chikungunya; In silico; Medicinal chemistry; Natural products; Synthesis.

Figures