Progress in targeting the BCL-2 family of proteins

The network of protein-protein interactions among the Bcl-2 protein family plays a critical role in regulating cellular commitment to mitochondrial Apoptosis. Anti-apoptotic Bcl-2 proteins are considered promising targets for drug discovery and exciting clinical progress has stimulated intense investigations in the broader family. Here, we discuss recent developments in small molecules targeting anti-apoptotic proteins and alternative approaches to targeting Bcl-2 Family interactions. These studies advance our understanding of the role of Bcl-2 Family proteins in physiology and disease, providing unique tools for dissecting these functions. The Bcl-2 Family of proteins is a prime example of targeting protein-protein interactions and further chemical biology approaches will increase opportunities for novel targeted therapies in Cancer, autoimmune and aging-associated diseases.