2. Academic Validation
  3. Iridoid Glycosides from the Twigs of Sambucus williamsii var. coreana and Their Biological Activities

Iridoid Glycosides from the Twigs of Sambucus williamsii var. coreana and Their Biological Activities

  • J Nat Prod. 2017 Sep 22;80(9):2502-2508. doi: 10.1021/acs.jnatprod.7b00410.
Won Se Suh 1,  Chung Sub Kim 1,  Lalita Subedi 2 3,  Sun Yeou Kim 2 3,  Sang Un Choi 4,  Kang Ro Lee 1
Affiliations

Affiliations

  • 1 Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University , Suwon 16419, Republic of Korea.
  • 2 Gachon Institute of Pharmaceutical Science, Gachon University , Incheon 21936, Republic of Korea.
  • 3 College of Pharmacy, Gachon University , #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.
  • 4 Korea Research Institute of Chemical Technology , Daejeon 34114, Republic of Korea.
PMID: 28841320 DOI: 10.1021/acs.jnatprod.7b00410
Abstract

Six new iridoid glycosides, sambucusides A-F (1-6), and two known derivatives (7 and 8) were isolated from a methanol extract of the twigs of Sambucus williamsii var. coreana. Their chemical structures were elucidated by spectroscopic methods, including NMR (1H and 13C NMR, 1H-1H COSY, HMQC, HMBC, and NOESY) and HRMS. All isolated compounds (1-8) were evaluated for their antiproliferative activities against four human Cancer cell lines (A549, SK-OV-3, SK-MEL-2, and Bt549). Their effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells and their neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells were also examined. Compounds 2, 3, and 5 showed cytotoxic effects (IC50 1.3-8.7 μM) against the SK-MEL-2 and Bt549 cell lines and inhibitory effects on NO production (IC50 of 0.9, 1.3, and 1.2 μM, respectively). Compounds 2, 4, and 8 exhibited NGF-releasing effects (147.0 ± 5.8%, 158.7 ± 5.2%, and 152.6 ± 7.3%, respectively).

Figures