2. Academic Validation
  3. The long noncoding RNA HOTAIR activates the Hippo pathway by directly binding to SAV1 in renal cell carcinoma

The long noncoding RNA HOTAIR activates the Hippo pathway by directly binding to SAV1 in renal cell carcinoma

  • Oncotarget. 2017 Apr 25;8(35):58654-58667. doi: 10.18632/oncotarget.17414.
Guanghui Hu  # 1,  Binbin Dong  # 2,  Jingwei Zhang  # 1,  Wei Zhai 1 3,  Tiancheng Xie 1,  Bisheng Huang 1,  Chi Huang 4,  Xudong Yao 1,  Junhua Zheng 1,  Jianping Che 1 4,  Yun-Fei Xu 1
Affiliations

Affiliations

  • 1 Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
  • 2 Department of Urology, Yancheng Third People's Hospital, Yancheng, Jiangsu, China.
  • 3 Department of Urology, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.
  • 4 Department of Urology, Shanghai Tenth People's Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
  • # Contributed equally.
PMID: 28938586 DOI: 10.18632/oncotarget.17414
Abstract

The long noncoding RNA HOTAIR promotes the development and progression of several tumors. Here, the clinical significance and role of HOTAIR in renal cell carcinoma (RCC) tumorigenesis were explored. The results showed that increased expression of HOTAIR predicted a poor prognosis of RCC after surgery. HOTAIR promoted RCC cell proliferation and growth in vitro and in vivo. The expressions of HOTAIR and Salvador homolog 1 (SAV1) were inversely correlated in clinical RCC samples. HOTAIR downregulated SAV1 by directly binding to the SAV1 protein and enhanced histone H3K27 methylation. Loss of function of SAV1 activated the Hippo pathway. HOTAIR could be a potential therapeutic target in RCC.

Keywords

HOTAIR; SAV1; hippo pathway; renal cell carcinoma.

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